Yun-Chen Tien, Ph.D.

Postdoctoral Fellow (2013-2016)

Current position: Scientist at Skyhawk Therapeutics, Waltham, MA

Education

1997-2001
BSc. in Nutrition
Hungkuang University
2003-2006
MSc. in Pharmacology
China Medical University
2007-2012
Ph.D. in Pharmacology
China Medical University

 

Professional Appointments

2013-2016
Postdoctoral Fellow
University of Connecticut, Storrs, CT
2016-2017
Research Scientist
Pfizer, Groton, CT
2018-2019
Research Scientist
Boston University Medical Center, Boston, MA
2019-
Scientist
Skyhawk Therapeutics, Waltham, MA

 

Professional Societies

2013-
Member of American Society for Pharmacology and Experimental Therapeutics (ASPET)

 

Honors and Awards

2014
1st Place of Postdoctoral Research Best Presentation Award in 19th North American ISSX/29th JSSX meeting in San Francisco
2015
1st Place of Postdoctoral Best Abstract Award issued by the Division for Drug Metabolism of ASPET at the Experimental Biology Meeting in Boston
2016
Travel award issued by the Division of Drug Metabolism of ASPET to attend the Experimental Biology Meeting in San Diego
2016
2015 James R. Gillette Best Paper Award in Drug Metabolism issued by the Executive Committee of the Division for Drug Metabolism of ASPET
2016
Final List in Postdoctoral Best Abstract Award Competition organized by the Division for Drug Metabolism of ASPET at the Experimental Biology Meeting in San Diego

 

Oral Presentations

10/2014
19th North American ISSX Meeting, San Francisco
“Impact of neonatal drug exposure on interindividual variations of P450-mediated drug metabolism”
04/2016
2016 Experimental Biology, Session of “Drug Metabolism Platform”, San Diego
“Impact of neonatal drug exposure on drug metabolism and therapeutic efficacy in adults”

 

Poster Presentations

04/2014
Experimental Biology, San Diego,
Peng L, Cui JY, Yoo B, Tien YC, Lu H, Klaassen CD, and Zhong XB. The role of FXR in the regulation of Phase-I drug metabolizing gene expression during mouse liver maturation.
04/2014
Experimental Biology, San Diego,
Cui JY, Peng L, Yoo B, Tien YC, Lu H, Zhong XB, and Klaassen CD. Developmental regulation of nuclear receptor mRNAs in livers of FXR-null mice.
10/2014
19th North American ISSX Meeting, San Francisco
Tien YC, Pope C, and Zhong XB. Impact of neonatal drug exposure on interindividual variations of P450-mediated drug metabolism.
03/2015
Experimental Biology, Boston
Tien YC, Liu K, Pope C, Ma X, and Zhong XB. Neonatal phenobarbital exposure with loading dose for seizures results in P450-mediated ultra-rapid drug metabolizers in adult mouse liver.
04/2016
Experimental Biology, San Diego
Tien YC, Pope C, Piekos S, and Zhong XB. 2016. Neonatal phenobarbital exposure results in decreased proton pump inhibition by omeprazole in adult mouse stomach.

 

Publications

Chen RJ, Wu HC, Chang MH, Lai CH, Tien YC, Hwang JM, Kuo WH, Tsai FJ, Tsai CH, Chen LM. Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Galphaq signaling. J Mol Endocrinol., 2009, 43(6):221-30. PMID: 19556392.

Peng WH, Tien YC, Huang CY, Huang TH, Liao JC, Kuo CL, Lin YC. Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. J Ethnopharmacol. 2010, 127(3):606-13. PMID: 20035854.

Tien YC, Lin JY, Lai CH, Kuo CH, Lin WY, Tsai CH, Tsai FJ, Cheng YC, Peng WH, Huang CY. Carthamus tinctorius L. prevents LPS-induced TNFalpha signaling activation and cell apoptosis through JNK1/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells. J Ethnopharmacol., 2010, 130(3):505-13. PMID: 20538053.

Shen JL, Chen YS, Lin JY, Tien YC, Peng WH, Kuo CH, Tzang BS, Wang HL, Tsai FJ, Chou MC, Huang CY, Lin CC. Neuron regeneration and proliferation effects of Danshen and Tanshinone IIA. Evid Based Complement Alternat Med. 2011, 378907. PMID: 21151668. PMCID: PMC2997511.

Tien YC, Liao JC, Chiu CS, Huang TH, Huang CY, Chang WT, Peng WH. Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. Int J Mol Sci., 2011, 12(6):4053-67. PMID: 21747724. PMCID: PMC3131608.

Li PC, Tien YC, Day CH, Pai P, Kuo WW, Chen TS, Kuo CH, Tsai CH, Ju DT, Huang CY. Impact of LPS-induced cardiomyoblast cell apoptosis inhibited by earthworm extracts. Cardiovasc Toxicol., 2015, 15(2):172-9. PMID: 25249212.

Wu CH, Wang CJ, Chang CP, Cheng YC, Song JS, Jan JJ, Chou MC, Ke YY, Ma J, Wong YC, Hsieh TC, Tien YC, Gullen EA, Lo CF, Cheng CY, Liu YW, Sadani AA, Tsai CH, Hsieh HP, Tsou LK, Shia KS. Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors. J Med Chem., 2015, 58(3):1452-65. PMID: 25584630.

Tracy TS, Chaudhry AS, Prasad B, Thummel KE, Schuetz EG, Zhong XB, Tien YC, Jeong H, Pan X, Shireman LM, Tay-Sontheimer J, and Lin YS. Interindividual variability in cytochrome P450 mediated drug metabolism. Drug Metabolism and Disposition, 2016, 44(3):343-351. PMID:26681736. PMCID:PMC4767386.

Tien YC, Liu K, Pope C, Wang P, Ma X, and Zhong XB. Dose of phenobarbital and age of treatment at early life are two key factors for the persistent induction of cytochrome P450 enzymes in adult mouse liver. Drug Metabolism and Disposition, 2015, 43(12):1938-1945. PMID:26400395. PMCID:PMC4658495.

Tien YC, Piekos SC, Pope C, and Zhong XB. Phenobarbital treatment at a neonatal age results in decreased efficacy of omeprazole in adult mice. Drug Metabolism and Disposition, 2017, 45(3):330-335. PMID:28062542.

 

Contact Information
Emailaustion23@gmail.com
203-645-4563