Yifan Bao
Ph.D. Student (2016-2021)
Current position: Scientist, Johnson & Johnson, Wayne, PA
Education
2012-2016
BSc. in Pharmacy
China Pharmaceutical University
2016-2018
MSc. in Pharmacology
University of Connecticut
2018-2021
Ph.D. in Pharmacology
University of Connecticut
Working Experience
2014
Internship in Pfizer Suzhou Pharmaceutical Plant
2021
Internship in Merck Sharp & Dohme Corp
2021-
Scientist, Johnson & Johnson, Wayne, PA
Professional Societies
2018-
Student Member, American Society of Pharmacology and Experimental Therapeutics (ASPET)
2018-
Student Member, International Society for the Study of Xenobiotics (ISSX)
2020-
Student Member, Society of Toxicology (SOT)
Honors and Awards
2020
The Edward A. and Lamia H. Khairallah Fellowship award ($1,000), University of Connecticut
2021
Doctoral Student Travel Fellowship from The Graduate School ($1,000), University of Connecticut
2021
Graduate Student Travel Award from ASPET at the Experimental Biology 2021 Virtual Meeting
2022
The Drug Metabolism and Disposition Highlighted Trainee Author in May 2022.
Poster Presentations
09/2017
21st North American ISSX Meeting, Providence, Rhode Island
Chen L, Bao Y, Piekos SC, and Zhong XB. The role of transcription factor HNF1a and long non-coding RNA HNF1a-AS1 in the regulation of cytochrome P450s and nuclear receptors in liver cells
02/2018
Keystone Symposium Noncoding RNAs: Form, Function, Physiology, Keystone, CO
Bao Y, Chen L, Piekos SC, and Zhong XB. The role of long non-coding RNAs HNF1a-AS1 and HNF4a-AS1 in the regulation of drug metabolizing cytochrome P450 enzymes and nuclear receptors in liver cells
04/2018
Experimental Biology Meeting, San Diego, CA
Chen L, Bao Y, Piekos SC, and Zhong XB. A transcriptional regulatory network containing nuclear receptors and long non-coding RNAs controls basal and induced expression of cytochrome P450s in liver cells
07/2019
12th International ISSX Meeting, Portland, OR
Bao Y, Shao X, Wang P, Zhu J, Xiao J, Shi J, Zhang L, Zhu HJ, Ma X, Manautou JE, and Zhong XB. Drug-induced liver injury alters expression and activities of drug-metabolizing cytochrome P450 enzymes in mouse liver at different ages
11/2020
3rd CALS Annual Symposium, virtual
Bao Y, Manautou JE, and Zhong XB. Alterations of drug metabolism and therapeutic efficacy during liver recovery and regeneration after acetaminophen-induced liver injury
04/2021
Experimental Biology Meeting, virtual
Bao Y, Zhu J, Ma X, Manautou JE, and Zhong XB. An injured liver caused by overdose of acetaminophen has altered expression and activities of P450 enzymes and associated drug efficacy during liver recovery and regeneration
Oral Presentations
11/2020
3rd CALS Annual Symposium, virtual
Alterations of drug metabolism and therapeutic efficacy during liver recovery and regeneration after acetaminophen-induced liver injury
04/2021
Experimental Biology Meeting, Session of Cross Talk in Metabolism of Xenobiotics and Endogenous Substrates, virtual
An injured liver caused by overdose of acetaminophen has altered expression and activities of P450 enzymes and associated drug efficacy during liver recovery and regeneration
Publications
Wang YB, Shang WD, Bao YF, Shi XW, Du YM, Cao DY, and Zhang K. Synthesis of regorafenib. Chinese Journal of Antibiotics, 2015, 08:590-592.
Chu X, Wang H, Jiang YM, Zhang YY, Bao YF, Zhang X, Zhang JP, Guo H, Yang F, Luan YC, and Dong YS. Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro. Journal of Pharmacological Sciences, 2016, 130(1):15-23. PMID:26810570
Bao Y, Ma X, Rasmussen TP, and Zhong XB. Genetic variations associated with anti-tuberculosis drug-induced liver injury. Current Pharmacology Reports, 2018, 4(3):171-181. PMID:20464886. PMCID:PMC6241288. DOI:10.1007/s40495-018-0131-8.
Chen L, Bao Y, Piekos SC, Zhu K, Zhang L, and Zhong XB. A transcriptional regulatory network containing nuclear receptors and lncRNAs controls basal and drug-induced expression of cytochrome P450s in HepaRG cells . Molecular Pharmacology, 2018, 94(1):749-759. PMID:29691280. PMCID:PMC5988030. DOI:10.1124/mol.118.112235.
Wang P, Shao X, Bao Y, Zhu J, Chen L, Zhang L, Ma X, and Zhong XB. Impact of obese levels on the hepatic expression of drug-processing genes in adult and offspring mice. Acta Pharmaceutica Sinica B, 2020, 10(1):171-185. PMID:31993314. PMCID:PMC6976990. DOI:10.1016/j.apsb.2019.10.009.
Bao Y, Wang P, Shao X, Zhu J, Xiao J, Shi J, Zhang L, Zhu HJ, Ma X, JManautou JE, and Zhong XB. Acetaminophen-induced liver injury alters expression and activities of cytochrome P450 enzymes in an age-dependent manner in mouse liver. Drug Metabolism and Disposition, 2020, 48(5):326-336. PMID:32094214. PMCID:PMC7153563. DOI:10.1124/dmd.119.089557.
Chen L, Bao Y, Jiang S, and Zhong XB. The roles of long noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in drug metabolism and human diseases. Non-coding RNA, 2020, 6(2):E24. PMID:32599764. PMCID:PMC7345002. DOI:10.3390/ncrna6020024.
Bao Y, Phan M, Zhu J, Ma X, Manautou JE, and Zhong XB. Alterations of cytochrome P450-mediated drug metabolism during liver repair and regeneration after acetaminophen-induced liver injury in mice. Drug Metabolism and Disposition, 2021, DMD-AR-2021-000459. PMID:34348940. DOI:10.1124/dmd.121.000459.
Ph.D. Thesis
Impact of drug-induced liver injury on drug-metabolizing cytochrome P450 enzymes
