Ye Li, Ph.D.

Postdoctoral Fellow (2006-2009)

Current position: Associate Professor at Capital Medical University, Beijing, China

Education

Professional Appointments

Professional Societies

Honors and Awards

Publications

Hart SN, Li Y, Nakamoto K, Wesselman C, and Zhong XB. Novel SNPs in cytochrome P450 oxidoreductase. Drug Metabolism and Pharmacokinetics, 2007, 22(4):322-326. PMID:17827787.

Hart SN, Wang S, Nakamoto K, Wesselman C, Li Y, and Zhong XB. Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catelyzed drug metabolism. Pharmacogenetics and Genomics, 2008, 18(1):11-24. PMID:18216718.

Li Y, Cui Y, Hart SN, Klaassen CD, and Zhong XB. Dynamic histone methylation is associated with ontogenic expression of Cyp3a genes during mouse liver maturation. Molecular Pharmacology, 2009, 75(5):1171-1179. PMID:19188337, PMCID:PMC2672803.

Li Y, Buckley D, Wang S, Klaassen CD, and Zhong XB. Genetic polymorphisms in the TATA box and upstream phenobarbital responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver. Drug Metabolism and Disposition, 2009, 37(9):1978-1986. PMID:19541828, PMCID:PMC2729330.

Hart SN, Li Y, Nakamoto K, Subileau E, Steen D, and Zhong XB. A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues. Drug Metabolism and Disposition, 2010, 38(6):988-994. PMID: 20228232, PMCID:PMC2879958.

Rodova M, Lu Q, Li Y, Woodbury B, Crist J, Gardner B, Yost J, Zhong XB, Anderson HC, and Wang J. Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone modifications. Journal of Bone and Mineral Research, 2011, 26(8):1974-1986. PMID:21452283. PMCID:PMC3353550.

Li Y and Zhong XB. Epigenetic regulation of developmental expression of Cyp2d genes in mouse liver. Acta Pharmaceutica Sinica B. 2012, 2(2):144-156.

Poster Presentations

Zhong XB, Li Y, Nakamoto K, Wesselman C, Kidd JR, Kidd KK, Jenison RD, Klaassen CD, and Wan YY. One Simple Step for Simultaneously Genotyping SNPs, Two-adjacent SNPs, Small Deletion/Insertion, and Microsatellite Repeat Polymorphisms for Pharmacogenomic Tests. 4^th Joint Cold Spring Harbor/Wellcome Trust Conference on Pharmacogenomics, Cold Spring Harbor Laboratory, New York, November 15-18, 2006.

Li Y, Wesselman C, Nakamoto K, and Zhong XB. Development of a Pharmacogenetic Test for Predicting Irinotecan Dosage in Colon and Rectal Cancer Chemotherapy. The Annual Meeting of the Central States Chapter of the Society of Toxicology, Kansas City, October 5-6, 2006

Li Y, Buckley D, Hart SN, Wesselman C, Nakamoto K, Klaassen CD, and Zhong XB. Genetic polymorphisms influence CYP2C9 enzyme activity for warfarin metabolism. International Heart Forum Beijing 2007, sponsored by Chinese Society of Cardiology, Beijing, China, September 21, 2007.

Hart SN, Wang S, Nakamoto K, Wesselman C, Li Y, and Zhong XB. Genetic polymorphisms in cytochrome P450 oxidoreductase influence P450-catalyzed drug metabolism and detoxification. The Annual Meeting of the Central States Chapter of the Society of Toxicology, Iowa City, September 20, 2007

Li Y, Buckley D, Wang S, Hart SN, Nakamoto K, Klaassen, CD, and Zhong XB. Genetic polymorphisms in the RNA polymerase II core promoter and enhancer elements of the UGT1A1 promoter influence its gene transcription. Experimental Biology 2008, April 5-9, San Diego.

Hart SN, Wang S, Nakamoto K, Wesselman C, Li Y, and Zhong XB. Single nucleotide polymorphisms in cytochrome P450 oxidoreductase influence drug metabolism. Experimental Biology 2008, April 5-9, San Diego.

Li Y, Cui Y, Hart SN, Klaassen CD, and Zhong XB. Dynamic histone methylation is associated with ontogenic expression of Cyp3a genes during mouse liver maturation. 2008 Annual Meeting of Central States Chapter of the Society of Toxicology, Kansas City, Kansas, September 24-25, 2008

Li Y, Cui Y, Hart SN, Klaassen CD, and Zhong XB. Dynamic histone methylation is associated with ontogenic expression of Cyp3a genes during mouse liver maturation. Keystone Symposia on Epigenetics, Development, and Human Disease, Breckenridge, Colorado, January 5-10, 2009.

Hart SN, Li Y, Cui Y, Klaassen CD, and Zhong XB. Dynamic DNA and histone methylation influences the ontogeny of xenobiotic metabolism genes during mouse liver maturation. 2009 Annual Symposium of Kansas IDeA Network of Biomedical Research Excellence, Manhattan, Kansas, January 17-18, 2009.

Li Y, Cui Y, Hart SN, Klaassen CD, and Zhong XB. Dynamic histone methylation is associated with ontogenic expression of Cyp3a genes during mouse liver maturation. 2009 Experimental Biology, New Orleans, Louisiana, April 18-22, 2009.

Hart SN, Li Y, Cui Y, Klaassen CD, and Zhong XB. Dynamic DNA and histone methylation influences the ontogeny of xenobiotic metabolism genes during mouse liver maturation. 2009 Experimental Biology, New Orleans, Louisiana, April 18-22, 2009.