Xiaobo Zhong, Ph.D.
Professor of Pharmacology & Toxicology
Department of Pharmaceutical Sciences
Education
1980-1984
BSc. in Biology
Peking University, Beijing, China
1991-1993
MSc. in Biotechnology
Wageningen University, The Netherlands
1993-1998
Ph.D. in Molecular Biology
Wageningen University, The Netherlands
Professional Appointments
1998-2001
Postdoctoral Associate
Yale University School of Medicine
2001-2004
Associate Research Scientist
Yale University School of Medicine
2004-2010
Assistant Professor
University of Kansas Medical Center
2010-2012
Associate Professor
University of Kansas Medical Center
2012-2017
Associate Professor
University of Connecticut
2017
Professor
University of Connecticut
Professional Societies
1995-1998
Member of International Society for Plant Molecular Biology
2000-2004
Member, American Society of Human Genetics
2005-2006
Member, International Society of Pharmacogenomics (ISP)
2006-2010
Member, Sigma Xi, Scientific Research Society
2007-2010
Secretary, Chapter of KUMC, Sigma Xi, Scientific Research Society
2007-
Member, American Society for Pharmacology and Experimental Therapeutics (ASPET)
2009-2012
Councilor, Division for Drug Metabolism of ASPET
2009-
Member, International Society for the Study of Xenobiotics (ISSX)
2010-
Member of the Chinese Biological Investigators Society (CBIS)
2010-
Member of the American Association for the Advancement of Science (AAAS)
2015-
Member of Sino-American Pharmaceutical Professionals Association (SAPA)
Honors and Awards
1991-1993
Fellowship in MSc Program of Biotechnology in Wageningen University, The Netherlands
1993-1998
Fellowship in Ph.D. Program of Molecular Genetics in Wageningen University, The Netherlands
1994
Travel Award, 4th International Congress of Plant Molecular Biology, Amsterdam, the Netherlands
1997
Travel Award, 5th International Congress of Plant Molecular Biology, Singapore
2000
Best Poster Award, Annual Retreat of the Department of Genetics, Yale University School of Medicine
2007-2008
RhRMA Foundation Research Starter Grant Award
2015
The James R. Gillette Drug Metabolism Best Paper of 2015 by the Journal of Drug Metabolism and Disposition
Professional Service on Editorial Boards
2010-
Editorial Board Member, Frontiers in Pharmacogenetics and Pharmacogenomics
2010-
Editorial Board Member, Journal of Drug Metabolism and Toxicology
2012-
Editorial Board Member, Drug Metabolism and Disposition (DMD)
2012-2013
Guest editor, Drug Metabolism and Disposition special issue on epigenetic regulation of drug metabolism enzymes and transporters
2015-
Editorial Board Member, Acta Pharmaceutica Sinica B (APSB)
2015-2016
Guest editor, Acta Pharmaceutica Sinica B special issue on drug metabolism and transport
2017-
Editorial Board Member, Nuclear Receptor Research
Ad Hoc Journal Review
Drug Metabolism and Disposition (DMD)
Molecular Pharmacology
Journal of Pharmacology and Experimental Therapeutics (JPET)
The Journal of Biological Chemistry (JBC)
Journal of Clinical Investigation (JCI)
Nucleic Acids Research (NAR)
Pharmacogenetics and Genomics
Pharmacogenomics
The Pharmacogenomics Journal
Biochimica et Biophysica Acta (BBA): Gene Regulatory Mechanisms
Pharmacology and Therapeutics
Journal of Drug Metabolism and Toxicology
Biochemical Pharmacology (BCP)
Frontiers in Pharmacogenetics and Pharmacogenomics
The Journal of Clinical Pharmacology
Toxicology and Applied Pharmacology
Journal of Human Genetics
Applied Microbiology and Biotechnology
Journal of Agricultural and Food Chemistry
Cell Biology and Toxicology
Pharmaceutical Sciences
Acta Pharmaceutica Sinica B
Scientific Report
Xenobiotica
PLoS ONE
Diseases
Nuclear Receptor Research
Ad Hoc Study Section Review
08/2009
NIH/NIDDK “Beta cell biology consortium collaborative bridging project program”
08/2010
The King Abdulaziz City for Science and Technology (KACST), the National Science Agency of Saudi Arabia
07/2011
Yale rheumatic diseases research core center pilot grants
11/2011
NIH Study Section ZRG1 CB-L 50 “Developmental Pharmacology”
11/2012
NIH Study Section ZRG1 CB-L 55 for “Developmental Pharmacology and Adverse Drug Reactions in Children”
07/2013
NIH Study Section ZRG1 CB-L 55 for “Developmental Pharmacology and Adverse Drug Reactions in Children”
06/2014
Veterans Affairs (VA) Study Section for Gastroenterology
11/2014
NIH Study Section ZRG1 DKUS C55 for “Role of Ontogeny in Developmental Pharmacology and Toxicology”
11/2015
NIH Study Section ZES1 LWJ-J (TG) for “Environmental Epigenomics Analysis in Tissue Surrogates (U01)”
11/2015
NIH Study Section ZES1 LWJ-J (U2) for “National Institute of Environmental Health Sciences Special Emphasis Panel”
02/2016
NIH Study Section ZRG1 GGG-K (50) for “Pharmacogenetics, pharmacoepigenetics, and personalized medicine in children”
02/2016
NIH Study Section ZGR1 BCMC-A (51) for Transformative R01 Application
11/2016
NIH Study Section ZRG1 DKUS-P (82) for Toxicology and Digestive, Kidney and Urological Systems AREA Review
03/2017
NSF The Division of Molecular and Cellular Biosciences (MCB)
10/2017
NIH Study Section ZCA1 SRB (J1) S NCI SEP2 for Provocative Questions
02/2018
NIH Study Section ZCA1 SRB (J1) S NCI SEP2 for Provocative Questions
Conference Organizer
2007
Session chair, “Clinical Pharmacology”, International Heart Forum, Beijing, China
2009
Session chair, “Clinical Pharmacology”, International Heart Forum, Beijing, China
2012
Session chair, “Novel Aspects of Non-coding RNAs in Regulation of ADME Genes”, 19th International Symposium on Microsomes and Drug Oxidations and 12th European ISSX Meeting, Noordwijk aan Zee, The Netherlands, June 2012
2013
Session chair, “Metabolism and Diseases”, 10th Biennial Conference of Chinese Biological Investigators Society, Cancun, Mexico, December 21-24, 2013
2014
Session chair, “Translational Medicine: from Clinical Studies to Clinical Practice”. 2014 China Heart Congress, Beijing, China, August 6-10, 2014
2014
Meeting Organization Committee member, 19th North American ISSX Meeting/29th JSSX Meeting, San Francisco, October 19-23, 2014
2014
Session chair, “Post-translational and Transcriptional Regulation of Transporters and Metabolism”, 19th North American ISSX Meeting/29th JSSX Meeting, San Francisco, October 19-23, 2014
2015
Session chair, “Precision Medicine in Pharmacotherapy”. 2015 China Heart Congress, Beijing, China, August 5-9, 2015
2016
Session chair, 11th Biennial Conference of Chinese Biological Investigators Society, Chengdu, China, July 29-August 1, 2016
2016
Meeting Organization Committee member, 21st International Symposium on Microsomes and Drug Oxidations, Davis, California, October 2-6, 2016
2016
Co-chair of the Best Poster Presentation Award Committee, 21st International Symposium on Microsomes and Drug Oxidations, Davis, California, October 2-6, 2016
2016
Session chair, “Roles of Long Non-coding RNAs in Liver Development, Functions, and Diseases”, 21st International Symposium on Microsomes and Drug Oxidations, Davis, California, October 2-6, 2016
2017
Meeting Organization Committee member, Advanced Workshop on Drug Metabolism and Precision Medicine, Zhengzhou, China, August 11-13, 2017
2017
Session chair, 2nd Ling-Nan International Conference on Pharmaceutical Sciences, Guangzhou, China, December 1-3, 2017
Invited Oral Presentation in Conferences and Institutions
06/1994
4th International Congress of Plant Molecular Biology, Amsterdam, The Netherlands
Localization of repetitive and single copy sequences on meiotic pachytene and mitotic metaphase chromosomes of tomato using fluorescence in situ hybridization (FISH)
08/1995
Symposium for Cell Function and Gene Regulation, Shanghai, China
Molecular cytogenetic analysis of the tomato genome using fluorescence in situ hybridization (FISH)
08/1996
International Symposium for Tomato Molecular Biology, Berkeley, California
Molecular cytogenetic analysis of the tomato genome by fluorescence in situ hybridization to pachytene chromosomes and extended DNA fibers
09/1997
5th International Congress of Plant Molecular Biology, Singapore
Toward the construction of a molecular cytogenetic ‘BAR CODE’ of tomato chromosome 6 using a monosomic addition in a tetraploid potato background
01/2000
Plant & Animal Genomes VIII Conference, San Diego
Rolling circle amplification: a new approach for detection of 50 base target sequences in cytological preparations
05/2002
Department of Plant Pathology, Kansas State University
Genotyping and haplotyping using rolling circle amplification and multiple displacement amplification technologies
01/2003
Plant & Animal Genomes XI Conference, Workshop: Molecular Markers, San Diego
SNP genotyping using oligonucleotide arrays on thin-film biosensor silicon chips
11/2003
The 1st International Rice Functional Genomics Symposium, Shanghai, China
Molecular genotyping in rice and other plant species on optical thin-film biosensor silicon chips
11/2003
Tsinghua University, Beijing, China
Optical thin-film biosensor chips for SARS virus detection, National Research Center for Microarray Chips
09/2007
2007 Beijing International Heart Forum, sponsored by Chinese Society of Cardiology, Beijing, China
Genetic polymorphisms influence CYP2C9 enzyme activity for warfarin metabolism
04/2009
2009 Experimental Biology Meeting, New Orleans, Louisiana
Programming ontogenic expression of P450 genes in mouse liver development by epigenetic mechanisms
09/2009
2009 International Heart Forum, Beijing
Pharmacoepigenetics and personalized medicine
07/2010
Gordon Conference on Drug Metabolism, Holderness, New Hampshire
Histone modifications in the regulation of drug-metabolizing P450 genes
09/2010
9th International ISSX Meeting, Istanbul, Turkey
Epigenetic control of ontogenicity of cytochrome P450 expression
06/2011
17th International Conference on Cytochrome P450, Manchester, UK
Role of CYP3A4 mRNA isoforms in hepatocyte differentiation and liver development
07/2011
Gordon Conference on Drug Metabolism, Holderness, New Hampshire
Developmental expression of CYP3A4 mRNA isoforms in hepatocyte maturation, fetal and adult liver
09/2011
1st International HepaRG Symposium, Rennes, France
RNA-Seq analysis of HepaRG transcriptome
01/2012
School of Pharmacy, University of Connecticut, Storrs
Genetic and epigenetic contributions to the variability of drug metabolism
03/2012
3rd Pediatric Pharmacogenomics and Personalized Medicine Conference. Kansas City, Missouri
Epigenetic mechanisms in regulation of ontogeny of cytochrome P450s
05/2012
Wadsworth Center, Albany, New York
Genetic and epigenetic contributions to the variability of P450-mediated drug metabolism
06/2012
19th MDO and 12th European Regional ISSX Meeting, Noordwijk, The Netherlands
Novel aspects of long non-coding RNAs in regulation of P450 genes
04/2013
2013 Experimental Biology Meeting, Boston
Chromatin interaction, epigenomics, and transcriptional response to drug induction
08/2013
Gordon Conference on Cellular and Molecular Mechanisms of Toxicity, Andover, New Hampshire
Chromatin interaction, epigenomics, and transcriptional response to drug induction
03/2014
2014 SOT Annual Meeting, Phoenix, Arizona
Hepatic ontogeny of drug processing genes in mouse liver
08/2014
2014 China Heart Congress, Beijing, China
Do we have a solution for personalized medicine?
11/2014
2014 AAPS Annual Meeting, San Diego
Epigenetic regulation of cytochrome P450s
03/2015
2015 Experimental Biology Meeting, Boston
Epigenetic regulation of cytochrome P450s
08/2015
2015 China Heart Congress, Beijing, China
Impact of neonatal drug exposure on personalized medicine
11/2015
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, Maryland
Impact of drug treatment in adult life following drug exposure at neonatal age
04/2016
2016 Experimental Biology Meeting, San Diego, California
Impact of drug exposure at early life on precision medicine
06/2016
Peking University School of Pharmacy, Beijing, China
Genetic and epigenetic contributions to the variability of drug metabolism and precision medicine
07/2016
Zhengzhou University School of Basic Medicine, Zhengzhou, China
Genetic and epigenetic contributions to the variability of drug metabolism and precision medicine
07/2016
China Pharmaceutical University, Nanjing, China
A new concept in precision medicine: impact of drug treatment at neonatal ages on drug metabolism and therapeutic efficacy in adult life
07/2016
11th Biennial CBIS Meeting, Chengdu, China
A new concept in precision medicine:impact on human health by neonatal drug treatment
10/2016
21st MDO Symposium, Davis, California
The role of long non-coding RNAs in postnatal liver maturation
08/2017
Advanced Workshop on Drug Metabolism and Precision Medicine, Zhengzhou, China
Fine tune regulation on drug metabolism and strategies for precision medicine
09/2017
21st North American ISSX Meeting, Providence, Rhode Island
Regulation of P450s by a network of transcription factors and long non-coding RNAs
11/2017
Department of Medicine at Albert Einstein College of Medicine, Bronx, New York
Impact by genetic, epigenetic, physiological, pathological, and environmental factors on drug metabolism and strategies for precision medicine
12/2017
Ling-Nan DMPK Forum, Guangzhou, China
Regulation of basal and induced expression of P450s in liver cells by a transcription factor network and long non-coding RNAs
Service for UConn Committee
2013-2017
Member of Institutional Animal Care and Use Committee (IACUC)
2017-2018
Member of Faculty Searching Committee for Attending Veterinarians
Service for School of Pharmacy
2017-
Member of Institutional Assessment Committee
Service for the Department at UConn
2014-
Coordinator of departmental seminar series
2013-2014
Chair of Faculty Searching Committee for Assistant or Associate Professor of Pharmacogenomics
2014-2015
Chair of Faculty Searching Committee for Assistant or Associate Professor of Systems Pharmacology
2015-2016
Member of Faculty Searching Committee for Boehringer Ingelheim Pharmaceuticals, Inc. Endowed Chair in Mechanistic Toxicology
2017
Member of Faculty Searching Committee for Assistant or Associate Professor of Neuropharmacology or Neurotoxicology
Teaching at UConn
Every Fall
PHAR 4000 “Pharmacogenomics and Personalized Medicine”
Co-coordinator
Pharm.D. and Ph.D.
Every Fall
PHAR 3030 “Pharmacokinetics and Biopharmaceutics”
Lecturer
Pharm.D.
Spring of even years
PHAR 5297 “Drug Discovery and Development”
Coordinator
Ph.D.
Spring of even years
PHAR 5297 “Drug Discovery and Development”
Lecturer
Ph.D.
Fall of odd years
PHAR 6455 “Advanced Toxicology”
Lecturer
Ph.D.
Spring of odd years
PHAR 5471 “Advanced Pharmacology I”
Lecturer
Ph.D.
Spring of odd years
GRAD 5910 “Responsible Conduct in Research”
Lecturer
Ph.D.
| xiaobo.zhong@uconn.edu | |
| Phone | 860-486-3697 |
| Fax | 860-486-5792 |
| Mailing Address | Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 N Eagleville Road, Storrs, CT 06269 |
| Office Location | PBB-538 |
| Campus | Storrs |
| Courses | PHAR 4000 "Pharmacogenomics and Personalized Medicine" and PHAR 5297 "Drug Discovery and Development" |