Liming Chen

Ph.D. Student (2016-2020)

Current position: Postdoctoral Fellow in the Beth Israel Deaconess Medical Center at Harvard Medical School

Education

2009-2013
BSc. in Pharmacy
Ocean University of China
2013-2016
MSc. in Pharmacology
St. John’s University
2016-2020
Ph.D. in Pharmacology
University of Connecticut

 

Working Experience

2012
Internship in Zibo Central Hospital, Shandong, China
2020-
Postdoctoral Fellow in the Beth Israel Deaconess Medical Center at Harvard Medical School, Boston, MA

 

Professional Societies

2014-
Member, Society of Toxicology (SOT)
2016-
Member, American Society for Pharmacology and Experimental Therapeutics (ASPET)
2017-
Member, International Society for the Study of Xenobiotics (ISSX)

 

Honors and Awards

2010
Outstanding Student Scholarship award, Ocean University of China
2011
University-level Merit Student award, Ocean University of China
2012
Award for Social Work, Ocean University of China
2017
2nd Place of Student Best Presentation Award in 2017 International Symposium on Drug Metabolism in Beijing, China
2018
A Graduate Student Travel Award ($800) from ASPET at the Experimental Biology 2018 Meeting in San Diego, CA
2018
Best Student Oral Presentation award at the Society of Toxicology Northeast Regional Chapter Annual Meeting in Rhode Island
2019
The Edward A. and Lamia H. Khairallah Fellowship award ($1,500), University of Connecticut
2020
The Molecular Pharmacology Highlighted Trainee Author in the issue of April 2020

 

Oral Presentations

10/2018
Society of Toxicology Northeast Regional Chapter in Rhode Island
Impact on acetaminophen-induced hepatotoxicity by long non-coding RNAs HNF1α-AS1 and HNF4α-AS1 in HepaRG cells
04/2019
Experimental Biology Meeting, Orlando, FL
Impact on acetaminophen-induced hepatotoxicity by long non-coding RNAs HNF1α-AS1 and HNF4α-AS1 in HepaRG cells

 

Poster Presentations

03/2015
54th SOT Annual Meeting, San Diego, California
Chen L, Patel BA, Talele T and Cheng XG. L-phenylalanine-derived rhodanine analog (lpar)-induced diverse cytoprotective mechanisms in cultured mouse and human hepatoma cells
03/2016
55th SOT Annual Meeting, New Orleans, Louisiana
Chen L and Cheng XG. Epalrestat caused apparent apoptosis in cultured mouse and human hepatoma cells
09/2017
21st North American ISSX Meeting, Providence, Rhode Island
Chen L, Bao Y, Piekos SC, and Zhong XB. The role of transcription factor HNF1a and long non-coding RNA HNF1a-AS1 in the regulation of cytochrome P450s and nuclear receptors in liver cells
09/2017
21st North American ISSX Meeting, Providence, Rhode Island
Piekos SC, Chen L, Ma X, Wang P, and Zhong XB. Short- and long-term effects on cytochrome P450 expression and induction following phenytoin exposure at the neonatal age
02/2018
Keystone Symposium Noncoding RNAs: Form, Function, Physiology, Keystone, CO
Bao Y, Chen L, Piekos SC, and Zhong XB. The role of long non-coding RNAs HNF1a-AS1 and HNF4a-AS1 in the regulation of drug metabolizing cytochrome P450 enzymes and nuclear receptors in liver cells
04/2018
Experimental Biology Meeting, San Diego, CA
Chen L, Bao Y, Piekos SC, and Zhong XB. A transcriptional regulatory network containing nuclear receptors and long non-coding RNAs controls basal and induced expression of cytochrome P450s in liver cells
04/2018
Experimental Biology Meeting, San Diego, CA
Shi J, Piekos SC, Chen L, Jing X, Zhong XB, and Zhu HJ. Short- and long-term effects of phenytoin exposure on the liver proteome of neonatal and adult mice using SWATH-MS technology
04/2019
Experimental Biology Meeting, Orlando, FL
Chen L, Manautou JE, and Zhong XB. Impact on acetaminophen-induced hepatotoxicity by long non-coding RNAs HNF1α-AS1 and HNF4α-AS1 in HepaRG cells

 

Publications

Pope C, Piekos SC, Chen L, Mishra S, and Zhong XB. The role of H19, a long non-coding RNA, in mouse liver postnatal maturation. PLoS ONE, 2017, 12(11):e0187557. PMID:29099871. PMCID:PMC5669494. DOI:10.1371/journal.pone.0187557.

Chen L, Bao Y, Piekos SC, Zhu K, Zhang L, and Zhong XB. A transcriptional regulatory network containing nuclear receptors and lncRNAs controls basal and drug-induced expression of cytochrome P450s in HepaRG cells . Molecular Pharmacology, 2018, 94(1):749-759. PMID:29691280. PMCID:PMC5988030. DOI:10.1124/mol.118.112235.

Piekos SC, Chen L, Wang P, Shi J, Yaqoob S, Zhu HJ, Ma X, and Zhong XB. Consequences of phenytoin exposure on hepatic cytochrome P450 expression during postnatal liver maturation in mice. Drug Metabolism and Disposition, 2018, 46(8):1241-1250. PMID:29884652. PMCID:PMC6053591. DOI:10.1124/dmd.118.080861.

Wang Y, Yan L, Liu J, Chen S, Liu G, Nie Y, Wang P, Yang W, Chen L, Zhong XB, Han S, and Zhang L. The HNF1α-regulated lncRNA HNF1α-AS1 is involved in the regulation of cytochrome P450 expression in human liver tissues and Huh7 cells. The Journal of Pharmacology and Experimental Therapeutics, 2019, 368(3):353-362. PMID:30602592. PMCID:PMC6367688. DOI:10.1124/jpet.118.252940.

Chen L, Manautou JE, Rasmussen TP, and Zhong XB. Development of precision medicine based on inter-individual variability of BCRP/ABCG2. Acta Pharmaceutica Sinica B, 2019, 9(4):659-674. PMID:31384528. PMCID:PMC6664102. DOI:10.1016/j.apsb.2019.01.007.

Chen L, Wang P, Bahal R, Manautou JE, and Zhong XB. Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver. PLoS One, 2019, 14(12):e0227102. PMID:31891622. PMCID:PMC6938302. DOI:10.1371/journal.pone.0227102.

Wang P, Shao X, Bao Y, Zhu J, Chen L, Zhang L, Ma X, and Zhong XB. Impact of obese levels on the hepatic expression of drug-processing genes in adult and offspring mice. Acta Pharmaceutica Sinica B, 2020, 10(1):171-185. PMID:31993314. PMCID:PMC6976990. DOI:10.1016/j.apsb.2019.10.009.

Chen L, Wang P, Manautou JE, and Zhong XB. Knockdown of long noncoding RNAs hepatocyte nuclear factor 1α antisense RNA 1 and hepatocyte nuclear factor 4α antisense RNA alters susceptibility of acetaminophen-induced cytotoxicity in HepaRG cells. Molecular Pharmacology, 2020, 97(4):278-286. PMID:32029527. PMCID:PMC7045890. DOI:10.1124/mol.119.118778.

Chen L, Bao Y, Jiang S, and Zhong XB. The roles of long noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in drug metabolism and human diseases. Non-coding RNA, 2020, 6(2):E24. PMID:32599764. PMCID:PMC7345002. DOI:10.3390/ncrna6020024.

 

Ph.D. Thesis

Chen L. Roles of long non-coding RNAs in the expression and function of hepatic P450s. Doctoral Dissertations, 2020, 2472. https://opencommons.uconn.edu/dissertations/2472/.

 

Contact Information
Emaillchen18@bidmc.harvard.edu
Mailing AddressCenter for Advanced Biomedical Imaging and Photonics, Department of Medicine, Beth Israel Deaconess Medical Center at Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215