Jing Jin

Postdoctoral Fellow

Department of Pharmaceutical Sciences

Education

Working Experience

Professional Societies

Honors and Awards

Poster Presentations

Oral Presentations

Ph.D. Thesis
Transcript-specific Roles of LncRNAs in Regulating P450-mediated Drug Metabolism
 

Research Articles
Zhao R, Jin J, Sun X, Jin K, Wang M, Ahmed MF, & Li B. The establishment of clonally derived chicken embryonic fibroblast cell line (CSC) with high transfection efficiency and ability as a feeder cell. Journal of cellular biochemistry, 2018, 119(11):8841-8850. PMID:30076744. DOI:10.1002/jcb.27137.

Jin J, Zhao R, Chen C, Zhou J, Lu Z, Jin K, & Li B. The Lbc gene promotes differentiation of chicken embryo stem cell into spermatogonial stem cells via the regulation of transcriptional factor Hoxa5. Journal of Cellular Biochemistry, 2019, 120(5):6952-6961. PMID:30656739. DOI:10.1002/jcb.27760.

Zuo Q, Jin J, Jin K, Sun C, Song J, Zhang Y, & Li B. Distinct roles of retinoic acid and BMP4 pathways in the formation of chicken primordial germ cells and spermatogonial stem cells. Food & function, 2019, 10(11):7152-7163. PMID:31596288. DOI:10.1039/c9fo01485c.

Zuo Q, Jin J, Jin K, Zhou J, Sun C, Song J, & Li B. P53 and H3K4me2 activate N6‐methylated LncPGCAT‐1 to regulate primordial germ cell formation via MAPK signaling. Journal of Cellular Physiology, 2020, 235(12):9895-9909. PMID:32458486. DOI:10.1002/jcp.29805.

Jin K, Li D, Jin J, Song J, Zhang Y, Chang G, & Li B. C1EIP functions as an activator of ENO1 to promote chicken PGC formation via the inhibition of Notch signaling pathway. Front Genet. 2020, 11:751. PMID:32849782. PMCID:PMC7396672. DOI:10.3389/fgene.2020.00751.

Wang S, Yuan X, Zhou J, Jin J, Zuo Q, and Li B. Comparison of the effects of three cryoprotectants on the cryopreservation of mouse subcutaneous tissue under different conditions. Exp Ther Med, 2020, 20(4):3285-3289. PMID:32855699. DOI:10.3892/etm.2020.9076. Epub 2020 Jul 29.

Jiang J, Chen C, Cheng S, Yuan X, Jin J, Zhang C, Sun X, Song J, Zuo Q, Zhang Y, Chen G, and Li B. Long noncoding RNA lncPGCR mediated by TCF7L2 regulates primordial germ cell formation in chickens. Animals (Basel), 2021, 11(2):292. PMID:33498947. DOI:10.3390/ani11020292.

Zuo Q, Jin J, Zhou J, Zhang Y, Wei W, Chen G, and Li B. Dual regulatory actions of LncBMP4 on BMP4 promote chicken primordial germ cell formation. EMBO Rep, 2022, 23(1):e52491. PMID:34747116. DOI:10.15252/embr.202152491

Jin J, Nguyen LTG, Wassef A, Sadek R, Schmitt TM, Guo GL, Rasmussen TP, and Zhong XB. Identification and functional characterization of alternative transcripts of lncRNA HNF1A-AS1 and their impacts on cell growth, differentiation, liver diseases, and in response to drug induction. Noncoding RNA, 2024, 10,28. PMID:38668386. PMCID:PMC11053763. DOI:10.3390/ncrna10020028.

Jin J, Nguyen LTG, Wassef A, Sadek R, Schmitt TM, Guo GL, Rasmussen TP, and Zhong XB. Correlations of lncRNA HNF4A-AS1 alternative transcripts with liver diseases and drug metabolism. Drug Metabolism and Disposition, 2024, 52(11):1345-1355. PMID: 39168525. DOI:10.1124/dmd.124.001873.

Nguyen LTG, Tawfik SM, Jin J, Durwin A, and Zhong XB. Impact on efficacy of target reduction of two FDA-approved ASO drugs by intracellular glucose levels in in vitro cell models. Molecular Therapy Nucleic Acids, 2025, 36(1):102487. PMID:40104114. PMCID:PMC11919288. DOI:10.1016/j.omtn.2025.102487.

Armanios B, Jin J, Kolmel H, Laddha AP, Mishra N, Manautou JE, and Zhong XB. Unraveling the regulatory impact of lncRNA Hnf1aos1 on hepatic homeostasis in mice. Noncoding RNA, 2025, 11(4):52. PMID:40700094. DOI:10.3390/ncrna11040052.

Jin J, Tawfik SM, Nguyen LTG, Armanios B, and Zhong XB. Visualization of CYP3A4 expression at both mRNA and protein levels simultaneously at single cell resolution in various conditions Using RNAscope combined with immunofluorescence. Drug Metabolism & Disposition, 2025, 53(9):100123. PMID:40850094. DOI:10.1016/j.dmd.2025.100123.

Tawfik SM, Nguyen LTG, Jin J, and Zhong XB. Intracellular fatty acid levels differentially impact target silencing by FDA-approved siRNA drugs. Biochemical Pharmacology, 2025, 242:117192. PMID:40730278. PMCID:PMC12339022. DOI:10.1016/j.bcp.2025.117192.

Tawfik SM, Nguyen LTG, Jin J, Armanios B, and Zhong XB. Cholesterol-dependent control of endosomal escape regulates intracellular trafficking of siRNA therapeutics and interactions with small molecule drugs. Journal of Pharmacology Experimental Therapeutics, 2026, 393(2):103802. PMID:41564596. DOI: 10.1016/j.jpet.2025.103802.

Armanios B, Jin J, Laddha AP, Nguyen LTG, Tawfik SM, Mishra N, Manautou JE, and Zhong XB. Hnf1aos1 as a metabolic coordinator of hepatic lipid homeostasis and feedback control. Noncoding RNA, 2026, 12(3):15. PMID:42200947. PMCID:PMC13214671. DOI:10.3390/ncrna12030015.

Nguyen LTG, Tawfik SM, Jin J, Durwin A, Armanios B, and Zhong XB. ESCRT-I complex enhances therapeutic efficacy of antisense oligonucleotide drugs by regulating endosomal escape and glucose homeostasis. Molecular Therapy Nucleic Acids, 2026, in press.
 

Review Articles
Migliorati JM, Jin J, and Zhong XB. Drug of the Month: siRNA drug Leqvio (inclisiran) to lower cholesterol. Trends in Pharmacological Sciences, 2022, 43(5):455-456. PMID:35307191. DOI:10.1016/j.tips.2022.02.003.

Jin J and Zhong XB. 50th anniversary celebration collection: Epigenetic mechanisms contribute to intraindividual variations of drug metabolism mediated by cytochrome P450 enzymes. Drug Metabolism and Disposition. 2023, 51(6):672-684. PMID:36973001. DOI:10.1124/dmd.122.001007.

Jin J, Armanios B, and Zhong XB. LncRNA MALR drives liquid–liquid phase separation to promote esophageal cancer process. The Non-Coding RNA Journal Club: Highlights on Recent Papers—12. Noncoding RNA, 2023, 9(2):28. PMID:37104010. PMCID:PMC10144170. DOI:10.3390/ncrna9020028.

Jin J and Zhong XB. ASO drug Qalsody (tofersen) targets amyotrophic lateral sclerosis. Trends in Pharmacological Sciences. 2023, 12:S0165-6147(23)00178-5. PMID:37709589. DOI:10.1016/j.tips.2023.08.008.

Gogate A, Belcourt J, Shah M, Wang AZ, Frankel A, Holly K, Chalon M, Stephen P, Kolli A, Tawfik SM, Jin J, Bahal R, Rasmussen TP, Manautou JE, and Zhong XB. Targeting the liver with nucleic acid therapeutics for the treatment of systemic diseases of liver origin. Pharmacological Reviews, 2024, 76(1):49-89. PMID:37696583. PMCID:PMC10753797. DOI:10.1124/pharmrev.123.000815.

Jin J, Nguyen LTG, Tawfik SM, Armanios B, and Zhong XB. The ASO drug olezarsen targets familial chylomicronemia syndrome. Trends in Pharmacological Sciences, 2025, S0165-6147(25)00097-5. PMID:40480844. DOI:10.1016/j.tips.2025.05.007.

Armanios B, Jin J, and Zhong XB. The Non-Coding RNA journal club: highlights on recent papers—14: 8 Functional conservation of lncRNAs between human and mouse in the regulation of metabolic functions in the liver. Noncoding RNA, 2025, 11(4):52. PMID: 40700094. PMCID: PMC12286052. DOI:10.3390/ncrna11040052.

Book Chapters
Jin J, Armanios B, Nguyen LTG, and Zhong XB. Epigenetic regulation of drug metabolism and transport by long noncoding RNAs. Pharmacoepigenetics, 2nd Edition. Elsevier, Hardback ISBN: 9780443187223. eBook ISBN: 9780443187230.

Armanios B, Jin J, and Zhong XB. Developmental regulation of drug metabolism and disposition. Drug Metabolism in Diseases, 2nd Edition, 495-513. Editor: Wen Xie. Academic Press, Hardback ISBN: 9780443292897. eBook ISBN: 9780443292903.
 

Patent Application
Zhong XB, Jin J, and Armanios B. HNF4A-AS1 Targeting Therapeutics and Uses Thereof. U.S. Provisional Application No. 63/995,368.