Beshoy Armanios

Ph.D. Candidate (2022-2026)

Department of Pharmaceutical Sciences

Education

2014-2018
BSc. in Biology and Psychology
Providence College, Providence, RI
2019-2021
MSc in Public Health
University of Massachusetts Amherst, School of Medicine, Worcester, MA
2022-2025
Ph.D. Student in Pharmacology
University of Connecticut School of Pharmacy, Storrs, CT
2025-2026
Ph.D. Candidate in Pharmacology
University of Connecticut School of Pharmacy, Storrs, CT

 

Working Experience

2017-2018
Student Research Intern, Massachusetts General Hospital, Boston, MA
2018
Radiology Authorization Specialist, Dana Farber Cancer Institute, Boston, MA
2019
Volunteer Research Technician, University of Massachusetts School of Medicine, Worcester, MA
2019-2021
Clinical Research Coordinator, Department of Neurology, University of Massachusetts School of Medicine, Worcester, MA
2021-2022
Research Assistant/Associate, Cyprotex an Evotec Company, Watertown, MA
2023
Summer Internship, Boehringer Ingelheim, Ridgefield, CT
2025
Summer Internship, Novo Nordisk, Lexington, MA

 

Honors and Awards

 

Extracurricular Activities

 

Poster Presentations

09/2024
26th North American ISSX and 39th JSSX Meeting, Honolulu, Hawaii
Armanios B, Jin J, Kolmel H, Nguyen LTG, Tawfik SM, and Zhong XB. The regulatory role of the lncRNA HNF1AOS1 in hepatic drug metabolism in mice
06/2026
ncRNA2026: From Molecular Mechanisms to Clinical Impact. Leuven, Belgium
Hnf1aos1 loss uncouples HNF1A activity from metabolic feedback control to drive uptake dominant hepatic steatosis

 

Publications
Jin J, Armanios B, Nguyen LTG, and Zhong XB. Epigenetic regulation of drug metabolism and transport by long noncoding RNAs. Pharmacoepigenetics, 2nd Edition, Editor: Ramón Cacabelos. May 2025. Elsevier, Hardback ISBN: 9780443187223. eBook ISBN: 9780443187230.

Nguyen J, Joseph D, Chen X, Armanios B, Sharma A, Stopfer P, and Huang F. Improving the working models for drug-drug interactions: impact on preclinical and clinical drug development. Pharmaceutics, 2025, 17(2):159. PMID:40006526. PMCID:PMC11859687. DOI:10.3390/pharmaceutics17020159.

Jin J, Nguyen LTG, Tawfik SM, Armanios B, and Zhong XB. The ASO drug olezarsen targets familial chylomicronemia syndrome. Trends in Pharmacological Sciences, 2025, S0165-6147(25)00097-5. PMID:40480844. PMCID: PMC12335367. DOI:10.1016/j.tips.2025.05.007.

Armanios B, Jin J, Kolmel H, Laddha AP, Mishra N, Manautou JE, and Zhong XB. Unraveling the regulatory impact of lncRNA Hnf1aos1 on hepatic homeostasis in mice. Noncoding RNA, 2025, 11(4):52. PMID:40700094. PMCID: PMC12286052. DOI:10.3390/ncrna11040052.

Jin J, Tawfik SM, Nguyen LTG, Armanios B, and Zhong XB. Visualization of CYP3A4 expression at both mRNA and protein levels simultaneously at single cell resolution in various conditions Using RNAscope combined with immunofluorescence. Drug Metabolism & Disposition, 2025, 53(9):100123. PMID:40850094. PMCID: PMC12597531. DOI:10.1016/j.dmd.2025.100123.

Armanios B, Jin J, and Zhong XB. The Non-Coding RNA journal club: highlights on recent papers—14: 8 Functional conservation of lncRNAs between human and mouse in the regulation of metabolic functions in the liver. Noncoding RNA, 2025, 11(4):52. DOI:10.3390/ncrna.

Armanios B, Jin J, and Zhong XB. Developmental regulation of drug metabolism and disposition. Drug Metabolism in Diseases, 2nd Edition, 495-513. Editor: Wen Xie. Academic Press, Hardback ISBN: 9780443292897. eBook ISBN: 9780443292903.

Tawfik SM, Nguyen LTG, Jin J, Armanios B, and Zhong XB*. Cholesterol-dependent control of endosomal escape regulates intracellular trafficking of siRNA therapeutics and interactions with small molecule drugs. J Pharmacol Exp Ther, 2026, 393(2):103802. PMID:41564596. DOI: 10.1016/j.jpet.2025.103802.

Armanios B, Jin J, Laddha A, Nguyen LTG, Tawfik SM, Mishra N, Manautou JE, and Zhong XB*. Hnf1aos1 as a metabolic coordinator of hepatic lipid homeostasis and feedback control. Non-coding RNA, 2026, 12(3):15. PMID:42200947. PMCID:PMC13214671. DOI:10.3390/ ncrna12030015.

Nguyen LTG, Tawfik SM, Jin J, Durwin A, Armanios B, and Zhong XB*. ESCRT-I complex enhances therapeutic efficacy of antisense oligonucleotide drugs by regulating endosomal escape and glucose homeostasis. Mol Ther Nucleic Acids, 2026.
 

Patent Application
HNF4A-AS1 Targeting Therapeutics and Uses Thereof
 

Ph.D. Thesis
Hnf1aos1 Deficiency Drives Diet‑Dependent Hepatic Steatosis in Mice
 

Contact Information
Alternate Phone860-486-6803
Mailing AddressDepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06269
Office LocationPBB-230A
Groups