Publications | Zhong Research Lab

Citations in Google Scholar

A full list of publications and citations in Google Scholar

2024

Jin J, Nguyen LTG, Wassef A, Sadek R, Schmitt TM, Guo GL, Rasmussen TP, and Zhong XB. Correlations of lncRNA HNF4A-AS1 alternative transcripts with liver diseases and drug metabolism. Drug Metabolism & Disposition, 2024. DOI:10.1124/dmd.187.

Zhong XB and Lai Y. Scientific Contributions to Drug Metabolism by Dr. Edward T. Morgan, the Recipient of the Bernard B. Brodie Award in Drug Metabolism and Disposition in 2024–Editorial. Drug Metabolism & Disposition, 2024, 52(10):1037-1038. PMID:39284706. DOI:10.1124/dmd.124.001911.

Lai Y and Zhong XB. Special section: Mechanisms of drug metabolism in acetaminophen-induced liver injury – Editorial. Drug Metabolism & Disposition, 2024, 52(8):704-706. PMID:39013582. DOI:10.1124/dmd.124.

Sang A, Zhou S, Bochanis A, Manautou JE, Bahal R, Zhong XB, and Rasmussen TP. Mechanisms of action of the U.S. Food and Drug Administration-approved antisense oligonucleotide drugs. BioDrugs, 2024, 38(4):511-526. PMID:38914784. DOI:10.1007/s40259-024-00665-2.

Zhong XB and Lai Y. Special section: Cytochrome P450 enzymes in toxicology and as drug targets – Editorial. Drug Metabolism & Disposition, 2024, 52(6):476-478. PMID:38754960. DOI:10.1124/dmd.124.001763.

Jin J, Nguyen LTG, Wassef A, Sadek R, Schmitt TM, Guo GL, Rasmussen TP, and Zhong XB*. Identification and functional characterization of alternative transcripts of lncRNA HNF1A-AS1 and their impacts on cell growth, differentiation, liver diseases, and in response to drug induction. Noncoding RNA, 2024, 10(2):28. PMID:38668386. PMCID:PMC11053763. DOI:10.3390/ncrna10020028.

Wang Y, Wang P, Wang Q, Chen S, Wang X, Zhong XB, Hu W, Thorne RF, Han S, Wu M, and Zhang L. The long noncoding RNA HNF1A-AS1 with dual functions in the regulation of cytochrome P450 3A4. Biochemical Pharmacology, 2024, 220:116016. DOI:10.1016/j.bcp.2023.116016.

Gogate A, Belcourt J, Shah M, Wang AZ, Frankel A, Holly K, Chalon M, Stephen P, Kolli A, Tawfik SM, Jin J, Bahal R, Rasmussen TP, Manautou JE, and Zhong XB. Targeting the liver with nucleic acid therapeutics for the treatment of systemic diseases of liver origin. Pharmacological Reviews, 2024, 76(1):49-89. PMID:37696583. PMCID: PMC10753797. DOI:10.1124/pharmrev.123.000815.

2023

Zhong XB, Lai Y, and Ding X. 50th anniversary celebration collection: Special section on new and emerging areas and technologies in drug metabolism and disposition, Part I–Editorial. Drug Metabolism and Disposition. 2023, 51(10):1227-1229. PMID:37709358. DOI:10.1124/dmd.123.001480.

Jin J and Zhong XB. ASO drug Qalsody (tofersen) targets amyotrophic lateral sclerosis. Trends in Pharmacological Sciences, 2023, 12:S0165-6147(23)00178-5. PMID:37709589. DOI:10.1016/j.tips.2023.08.008.

Lai Y and Zhong XB. 50th anniversary celebration collection: Special section on mechanism-based predictive methods in drug discovery and development - Editorial. Drug Metabolism and Disposition. 2023, 51(9):1064-1066. PMID:37586888. DOI:10.1124/dmd.123.001456.

Ranjbar S, Zhong XB, J Manautou, and Lu X. A holistic analysis of the intrinsic and delivery-mediated toxicity of siRNA therapeutics. Advanced Drug Delivery Reviews. 2023, 201:115052. PMID:37567502. PMCID: PMC10543595. DOI:10.1016/j.addr.2023.115052.

Zhong XB and Ding X. 50th anniversary celebration collection: Special section on perspectives on drug metabolism and disposition, Part II - Editorial. Drug Metabolism and Disposition. 2023, 51(8):902-903. PMID:37451979. DOI:10.1124/dmd.123.001407.

Jin J, Armanios B, and Zhong XB. LncRNA MALR drives liquid–liquid phase separation to promote esophageal cancer process. The Non-Coding RNA Journal Club: Highlights on Recent Papers—12. Noncoding RNA, 2023, 9(2):28. PMID:37104010. PMCID:PMC10144170. DOI:10.3390/ncrna9020028.

Jin J and Zhong XB. 50th anniversary celebration collection: Epigenetic mechanisms contribute to intraindividual variations of drug metabolism mediated by cytochrome P450 enzymes . Drug Metabolism and Disposition, 2023, 51(6):672-684. PMID:36973001. PMCID:PMC10197210. DOI:10.1124/dmd.122.001007.

Jing Jin was selected as Drug Metabolism and Disposition highlighted training author in June 2023.

Zhong XB and Lai Y. 50th anniversary celebration collection: Special section on drug metabolism and precision medicine - Editorial. Drug Metabolism and Disposition. 2023, 51(3):348-349. PMID:36849441. DOI:10.1124/dmd.122.001243.

Zhong XB and Lai Y. 50th anniversary celebration collection: Special section on xenobiotic receptors - Editorial. Drug Metabolism and Disposition. 2023, 51(2):205-206. PMID:36702490. DOI:10.1124/dmd.122.001207.

2022

Wu H, Wahane A, Alhamadani F, Zhang K, Parikh R, Lee S, McCabe EM, Rasmussen TP, Bahal R, Zhong XB, and Manautou JE. Nephrotoxicity of marketed antisense oligonucleotide drugs. Current Opinion in Toxicology, 2022, 32:100373. PMCID:PMC10174585. DOI:10.1016/j.cotox.2022.100373.

Liu A, Zhao J, Shah M, Migliorati JM, Tawfik SM, Bahal R, Rasmussen TP, Manautou JE, and Zhong XB. Nedosiran, a candidate siRNA drug for the treatment of primary hyperoxaluria: design, development, and clinical studies. ACS Pharmacol Transl Sci, 2022, 5(11):1007-1016. PMID:36407951. PMCID:PMC9667536. DOI:10.1021/acsptsci.2c00110.

Dhuri K, Shi J, Anastasiadou E, Slack FJ, Gupta A, Zhong XB, and Bahal R. Simultaneous targeting of multiple oncomiRs with phosphorothioate or PNA-based anti-miRs in lymphoma cell lines. Pharm Res. 2022, 39(11):2709-2720. PMID:36071352. PMCID: PMC9879158. DOI:10.1007/s11095-022-03383-y.

Lai Y and Zhong XB. Special section on mechanistic and translational research on transporters in toxicology- Editorial. Drug Metabolism and Disposition. 2022, 50(10):1361-1363. PMID:36127133. DOI:10.1124/dmd.122.001042.

Lai Y and Zhong XB. Special section on new era of transporter science: unraveling the functional role of orphan transporters - Editorial. Drug Metabolism and Disposition. 2022, 50(9):1190-1192. DOI:10.1124/dmd.122.001014.

Zhong XB and Lai Y. Special section on drug metabolism and regulation - Editorial. Drug Metabolism and Disposition. 2022, 50(7):998-999. PMID:35817440. DOI:10.1124/dmd.122.000925.

Migliorati J, Liu S, Liu A, Gogate A, Nair S, Bahal R, Rasmussen TP, Manautou JE, and Zhong XB. Absorption, distribution, metabolism, and excretion of US Food and Drug Administration-approved antisense oligo nucleotide drugs. Drug Metabolism and Disposition, 2022, 50(6):888-897. PMID:35221287. DOI:10.1124/dmd.121.000417.

Alhamadani F, Zhang K, Parikh R, Wu H, Bahal R, Rasmussen TP, Zhong XB*, and Manautou JE*. Adverse drug reactions and toxicity of the Food and Drug Administration-approved antisense oligo nucleotide drugs. Drug Metabolism and Disposition, 2022, 50(6):879-887; PMID:35221289. DOI:10.1124/dmd.121.000418.

Lai Y and Zhong XB. Special section on pharmacokinetics and ADME of biological therapeutics - Editorial. Drug Metabolism and Disposition. 2022, 50(6):819-821. PMID:35732334. DOI:10.1124/dmd.122.000896.

Wang X, Yu Y, Wang P, Yang K, Wang Y, Yan L, Ma X, Zhong XB, and Zhang L. Long noncoding RNAs hepatocyte nuclear factor 1A antisense RNA 1 and hepatocyte nuclear factor 4A antisense RNA 1 are involved in ritonavir-induced cytotoxicity through histone modifications in hepatoma cells. Drug Metabolism and Disposition, 2022, 50(5):704-715. PMID:34949673. PMCID:PMC9132102. DOI: https://doi.org/10.1124/dmd.121.000693.

Bao Y, Phan M, Zhu J, Ma X, Manautou JE, and Zhong XB. Alterations of cytochrome P450-mediated drug metabolism during liver repair and regeneration after acetaminophen-induced liver injury in mice. Drug Metabolism and Disposition, 2022, 50(5):694-703. PMID:34348940. PMCID:PMC9132219. DOI:https://doi.org/10.1124/dmd.121.000459.

Yifan Bao was selected as Drug Metabolism and Disposition highlighted training author in May 2022.

Zhong XB and Lai Y. Special Section on Drug Metabolism in Liver Injury and Repair - Editorial. Drug Metabolism and Disposition. 2022, 50(5):634-635. PMID: 35562120. DOI: https://doi.org/10.1124/dmd.122.000869.

Migliorati JM, Jin J, and Zhong XB. Drug of the Month: siRNA drug Leqvio (inclisiran) to lower cholesterol. Trends in Pharmacological Sciences, 2022, 43(5):455-456. PMID: 35307191. DOI: 10.1016/j.tips.2022.02.003.

Rizzolo D, Kong B, Piekos S, Chen L, Zhong XB, Lu J, Wang P, Ma X, Xie W, Zhu H, Yang Q, Li A, Wang H, Siemiatkowska AS, Kagan L, and Guo GL. Effects of overexpression of fibroblast growth factor 15/19 on hepatic drug metabolizing enzymes. Drug Metabolism and Disposition, 2022, 50(4):468-477. PMID: 34965924. DOI: 10.1124/dmd.121.000416.

Zhong XB and Lai Y. Special Section on Bile Acids, Drug Metabolism, and Toxicity—Editorial. Drug Metabolism and Disposition, 2022, 50(4):422-424. PMID:35410872. DOI:10.1124/dmd.122.000835.

Migliorati J and Zhong XB. Spotlight: Mutations in muscle-type creatine kinase impact HIV prevention. Trends in Pharmacological Sciences, 2022, 43(3):165-167. PMID:34887127. DOI:10.1016/j.tips.2021.11.017.

2021

Bao Y, Impact of Drug-induced liver injury on drug-metabolizing cytochrome P450 enzymes. Doctoral Dissertations, 2021. https://opencommons.uconn.edu/dissertations/.

Pande P, Role of histone methyltransferase enzyme G9a in transcriptional regulation of nuclear receptors and drug metabolizing P450 genes at basal level and in free fatty acid induced steatosis. Doctoral Dissertations, 2021. https://opencommons.uconn.edu/dissertations/.

Wang P, Chen S, Wang Y, Wang X, Yan L, Zhong XB, Han S, Yang K, and Zhang L. The long noncoding RNA hepatocyte nuclear factor 4α antisense RNA 1 negatively regulates cytochrome P450 enzymes in Huh7 cells via histone modifications. Drug Metabolism and Disposition, 2021, 49(5):361-368. PMID:33674270. DOI:10.1124/dmd.120.000316.

Zhang MM, Bahal R, Rasmussen TP, Manautou JE, and Zhong XB. The growth of siRNA-based therapeutics: updated clinical studies. Biochemical Pharmacology, 2021, 189:114432. PMID:33513339. PMCID:PMC8187268. DOI: 10.1016/j.bcp.2021.114432.

2020

Chen L. Roles of long non-coding RNAs in the expression and function of hepatic P450s. Doctoral Dissertations, 2020, 2472. https://opencommons.uconn.edu/dissertations/2472/.

Pande P, Zhong XB, and Ku W. Histone methyltransferase G9a regulates expression of nuclear receptors and cytochrome P450 enzymes in HepaRG cells at basal level and in fatty acid induced steatosis. Drug Metabolism and Disposition, 2020, 48(12):1321-1329. PMID: 33077425. DOI: 10.1124/dmd.120.000195.

Malik S, Gupta A, Zhong XB, Rasmussen TP, Manautou JE, and Bahal R. Emerging therapeutic modalities against COVID-19. Pharmaceuticals, 2020, 13(8):E188. PMID:32784499. PMCID:PMC7465781. DOI:10.3390/ph13080188.

Chen L, Bao Y, Jiang S, and Zhong XB. The roles of long noncoding RNAs HNF1α-AS1 and HNF4α-AS1 in drug metabolism and human diseases. Noncoding RNA, 2020, 6(2):E24. PMID:32599764. PMCID:PMC7345002. DOI:10.3390/ncrna6020024.

Bao Y, Wang P, Shao X, Zhu J, Xiao J, Shi J, Zhang L, Zhu HJ, Ma X, Manautou JE, and Zhong XB. Acetaminophen-induced liver injury alters expression and activities of cytochrome P450 enzymes in an age-dependent manner in mouse liver. Drug Metabolism and Disposition, 2020, 48(5):326-336. PMID:32094214. PMCID:PMC7153563. DOI:10.1124/dmd.119.089557.

Chen L, Wang P, Manautou JE, and Zhong XB. Knockdown of long noncoding RNAs hepatocyte nuclear factor 1α antisense RNA 1 and hepatocyte nuclear factor 4α antisense RNA alters susceptibility of acetaminophen-induced cytotoxicity in HepaRG cells. Molecular Pharmacology, 2020, 97(4):278-286. PMID:32029527. PMCID:PMC7045890. DOI:10.1124/mol.119.118778.

Liming Chen was selected as Molecular Pharmacology highlighted training author in April 2020.

Wang P, Shao X, Bao Y, Zhu J, Chen L, Zhang L, Ma X, and Zhong XB. Impact of obese levels on the hepatic expression of drug-processing genes in adult and offspring mice. Acta Pharmaceutica Sinica B, 2020, 10(1):171-185. PMID:31993314. PMCID:PMC6976990. DOI:10.1016/j.apsb.2019.10.009.

2019

Chen L, Wang P, Bahal R, Manautou JE, and Zhong XB. Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver. PLoS One, 2019, 14(12):e0227102. PMID:31891622. PMCID:PMC6938302. DOI:10.1371/journal.pone.0227102.

Wang P, Liu G, Nie Y, Han S, Li J, Zhong XB, and Zhang L. Epigenetic memory is involved in the persistent alterations of drug-processing genes in adult mice due to PCN-activated PXR during early life. Toxicological Sciences, 2019, 172(1):98-108. PMID:31388680. DOI:10.1093/toxsci/kfz177.

Wang P, Zhu J, Shehu AI, Lu J, Chen J, Zhong XB, and Ma X. Enzymes and pathways of kavain bioactivation and biotransformation. Chemical Research in Toxicology, 2019, 32(7):1335-1342. PMID:31265262. DOI:10.1021/acs.chemrestox.9b00098.

Chen L, Manautou JE, Rasmussen TP, and Zhong XB. Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2. Acta Pharmaceutica Sinica B, 2019, 9(4):659-674. PMID:31384528. PMCID:PMC6664102. https://doi.org/10.1016/j.apsb.2019.01.007.

Wang Y, Yan L, Liu J, Chen S, Liu G, Nie Y, Wang P, Yang W, Chen L, Zhong XB, Han S, and Zhang L. The HNF1α-regulated lncRNA HNF1α-AS1 is involved in the regulation of cytochrome P450 expression in human liver tissues and Huh7 cells. The Journal of Pharmacology and Experimental Therapeutics, 2019, 368(3):353-362. PMID:30602592. PMCID:PMC6367688. DOI:10.1124/jpet.118.252940.

Wu KC, Cui JY, Liu J, Lu H, Zhong XB, and Klaassen CD. RNA-Seq provides new insights on the relative mRNA abundance of antioxidant components during mouse liver development. Free Radical Biology and Medicine, 2019, 134(1):335-342. PMID:30659941. PMCID:PMC6588412. DOI:10.1016/j.freeradbiomed.2019.01.017.

2018

Piekos SC. Consequences of antiepileptic drug exposure during postnatal liver development on cytochrome P450 expression and metabolism. Doctoral Dissertations, 2018, 1850. https://opencommons.uconn.edu/dissertations/1850.

Heinrich A, Zhong XB, and Rasmussen TP. Variability in expression of the human MDR1 drug-efflux transporter and genetic variation of the ABCB1 gene: implications for drug-resistant epilepsy. Current Opinion in Toxicology, 2018, 11-12:35-42. PMID:31602418. PMCID:PMC6785833. DOI:10.1016/j.cotox.2018.12.004.

Wang P, Sachar M, Guo GL, Shehu AI, Lu J, Zhong XB, and Ma X. Liver metabolomics in a mouse model of erythropoietic protoporphyria. Biochemical Pharmacology, 2018, 254:474-481. PMID:29906468. PMCID:PMC6310158. DOI:10.1016/j.bcp.2018.06.011.

Piekos SC, Chen L, Wang P, Shi J, Yaqoob S, Zhu HJ, Ma X, and Zhong XB. Consequences of phenytoin exposure on hepatic cytochrome P450 expression during postnatal liver maturation in mice. Drug Metabolism and Disposition, 2018, 46(8):1241-1250. PMID:29884652. PMCID:PMC6053591. DOI:10.1124/dmd.118.080861.

Kong B, Sun R, Huang M, Chow MD, Zhong XB, Xie W, Lee YH, and Guo GL. A novel fibroblast growth factor 15 dependent- and bile acid independent-promotion of liver regeneration in mice. Hepatology, 2018, PMID:29672888. PMCID:PMC6195490. DOI:10.1002/hep.30041.

Chen L, Bao Y, Piekos SC, Zhu K, Zhang L, and Zhong XB. A transcriptional regulatory network containing nuclear receptors and lncRNAs controls basal and drug-induced expression of cytochrome P450s in HepaRG cells. Molecular Pharmacology, 2018, 94(1):749-759. PMID:29691280. PMCID:PMC5988030. DOI:10.1124/mol.118.112235.

Bao Y, Ma X, Rasmussen TP, and Zhong XB. Genetic variations associated with anti-tuberculosis drug-induced liver injury. Current Pharmacology Reports, 2018, 4(3):171-181. PMID:20464886. PMCID:PMC6241288. DOI:10.1007/s40495-018-0131-8.

2017

Pope C. The role of H19, a long non-coding RNA, in liver development. Doctoral Dissertations, 2017, 1588. https://opencommons.uconn.edu/dissertations/1588.

Pope C, Piekos SC, Chen L, Mishra S, and Zhong XB. The role of H19, a long non-coding RNA, in mouse liver postnatal maturation. PLoS ONE, 2017, 12(11):e0187557. PMID:29099871. PMCID:PMC5669494. DOI:/10.1371/journal.pone.0187557.

Peng L, Piekos SC, Guo GL, and Zhong XB. Role of farnesoid X receptor in the determination of liver transcriptome during postnatal maturation in mice. Nuclear Receptor Research, 2017, Vol. 4:ID 101308. PMID:29795774. PMCID:PMC5962295. DOI:10.11131/2017/101308.

Wang P, Shehu AI, Lu J, Joshi RH, Venkataramanan R, Sugamori KS, Grant DM, Zhong XB, and Ma X. Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. Biochemical Pharmacology, 2017, 145:218-225. PMID:28888949. PMCID:PMC5681379. DOI:10.1016/j.bcp.2017.09.001.

Yan L, Wang Y, Liu J, Nie Y, Zhong XB, Kan Q, and Zhang L. Alterations of histone modifications contribute to pregnane X receptor-mediated induction of CYP3A4 by rifampicin. Molecular Pharmacology, 2017, 92(2):113-123. PMID:28546420. PMCID:PMC5508193. DOI:10.1124/mol.117.108225.

Song Y, Liu C, Liu X, Trottier J, Beaudoin M, Zhang L, Pope C, Peng G, Barbier O, Zhong XB, Li L, and Wang L. H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of EpCAM. Hepatology, 2017, 66(4):1183-1196. PMID:28407375. PMCID:PMC5605402. DOI:10.1002/hep.29209.

Bindu P, Zhong XB, and Rasmussen T. Exploiting long noncoding RNAs as pharmacological targets to modulate epigenetic disease. Yale Journal of Biology and Medicine, 2017, 90(1):73-86. PMID:28356895. PMCID:PMC5369047.

Piekos SC and Zhong XB. Supplement on Editors' Picks of Drug Metabolism and Disposition, 43:1938-1945. World Biomedical Frontiers, Editors' Picks, 2017 Mar 12.

Pope C, Mishra S, Russell J, Zhou Q, and Zhong XB. Targeting H19, an imprinted long non-coding RNA, in hepatic functions and liver diseases. Diseases, 2017, 5(1):11. PMID:28933364. PMCID:PMC5456333. DOI:10.3390/diseases5010011.

Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan EM, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, and Zhong XB. Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21^st MDO. Acta Pharmaceutica Sinica B, 2017, 7(2):241-248. PMID:28388695. PMCID:PMC5343155. DOI:10.1016/j.apsb.2016.12.006.

Piekos SC, Pope C, Ferrara A, and Zhong XB. Impact of drug treatment at neonatal ages on variability of drug metabolism and drug-drug interactions in adult life. Current Pharmacology Reports, 2017, 3(1):1-9. PMID:28344923. PMCID:PMC5362116. DOI:10.1007/s40495-016-0078-6.

Tien YC, Piekos SC, Pope C, and Zhong XB. Phenobarbital treatment at a neonatal age results in decreased efficacy of omeprazole in adult mice. Drug Metabolism and Disposition, 2017, 45(3):330-335. PMID:28062542. PMCID:PMC5325062. DOI:10.1124/dmd.116.073601.

2016

Peng L, Piekos S, Guo GL, and Zhong XB. Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver. Acta Pharmaceutica Sinica B, 2016, 6(5):453-459. PMID:27709014. PMCID:PMC5054554.

Wang P, Pradhan K, Zhong XB, and Ma X. Isoniazid metabolism and hepatotoxicity. Acta Pharmaceutica Sinica B, 2016, 6(5):384-392. PMID:27709007. PMCID:PMC5045547.

Yu AM and Zhong XB. Advanced knowledge in drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B, 2016, 6(5):361-362. PMID:27709004. PMCID:PMC5045544.

Zhang M, Lu Q, Egan B, Zhong XB, Brandt K, and Wang J. Epigenetically mediated spontaneous reduction of NFAT1 expression causes imbalanced metabolic activities of articular chondrocytes in aged mice. Osteoarthritis and Cartilage, 2016, 24(7):1274-1283. PMID:26903200. PMCID:PMC4907852.

Tracy TS, Chaudhry AS, Prasad B, Thummel KE, Schuetz EG, Zhong XB, Tien YC, Jeong H, Pan X, Shireman LM, Tay-Sontheimer J, and Lin YS. Interindividual variability in cytochrome P450 mediated drug metabolism. Drug Metabolism and Disposition, 2016, 44(3):343-351. PMID:26681736. PMCID:PMC4767386.

2015

Tien YC, Liu K, Pope C, Wang P, Ma X, and Zhong XB. Dose of phenobarbital and age of treatment at early life are two key factors for the persistent induction of cytochrome P450 enzymes in adult mouse liver. Drug Metabolism and Disposition, 2015, 43(12):1938-1945. PMID:26400395. PMCID:PMC4658495.

Dr. Tien was awarded as the 2016 James R. Gillette Best Paper Award for Drug Metabolism by Drug Metabolism and Disposition in April 2016.

Gunewardena SS, Yoo B, Peng L, Lu H, Zhong XB, Klaassen CD, and Cui JY. Deciphering the developmental dynamics of the mouse liver transcriptome. PLoS ONE, 2015, 10(10):e0141220. PMID:26496202. PMCID:PMC4619800.

Peng L and Zhong XB. Epigenetic regulation of drug metabolism and transport. Acta Pharmaceutica Sinica B. 2015, 5(2):106-112. PMID:26579435. PMCID:PMC4629221.

2014

Peng L. Developmental regulation of phase-I drug metabolizing enzyme genes in mouse liver. Doctoral Dissertations, 2014, 451. http://digitalcommons.uconn.edu/dissertations/451.

Peng L, Paulson A, Li H, Piekos S, He X, Li L, and Zhong XB. Developmental programming of long non-coding RNAs during postnatal liver maturation in mice. PLoS ONE, 2014, 9(12):e114917. PMID:25503252. PMCID:PMC3834128. PDF.

Zhan L, Liu H, Fang Y, Kong B, He Y, Zhong XB, Fang J, Wan, and Guo GL. Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes and HepG2 cells. PLoS ONE, 2014, 9(8):e105930. PMID:25198545. PMCID:PMC4157742.

Renaud H, Cui JY, Lu H, Zhong XB, and Klaassen CD. Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-Sequencing. PLoS ONE, 2014, 9(8):e104560. PMID:25102070. PMCID:PMC4125194.

2013

Peng L, Cui JY, Yoo B, Gunewardena SS, Lu H, Klaassen CD, and Zhong XB. RNA-Sequencing quantification of hepatic ontogeny of phase-I enzymes in mice. Drug Metabolism and Disposition, 2013, 41(12):2175-2186. PMID:24080161. PMCID:PMC3834128.

Ingelman-Sundberg M, Zhong XB, Hankinson O, Beedanagari S, Yu AM, Peng L, and Osawa Y. Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. Drug Metabolism and Disposition, 2013, 41(10):1725-1731. PMID:23918665. PMCID:PMC3781370.

Zhong XB and Leeder JS. Epigenetic regulation of ADME-related genes: focus on drug metabolism and transport. Drug Metabolism and Disposition, 2013, 41(10): 1721-1724. PMID:23935066. PMCID:PMC3920173.

Venkatraman A, He XC, Thorvaldsen J, Sugimura R, Perry JM, Zhao M, Christiansen MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemmens TL, Bartolomei M, and Li L. Maternal-specific imprinting in the H19-Igf2 locus maintains quiescent long-term hematopoietic stem cells. Nature 2013, 500(7462):345-349. PMID:23863936. PMCID:PMC3896866.

Thomas AM, Hart SN, Li G, Lu H, Fang YP, Fang JW, Zhong XB, and Guo GL. Hepatocyte nuclear factor 4 alpha and farnesoid X receptor co-regulates gene transcription in mouse livers on a genome-wide scale. Pharmaceutical Research, 2013, 30(9):2188-2198. PMID:23462932. PMCID:PMC3711942.

Lu H, Gunewardena S, Cui JY, Yoo B, Zhong XB, and Klaassen CD. RNA-Sequencing quantification of hepatic ontogeny and tissue distribution of mRNA of phase II enzymes in mice. Drug Metabolism and Disposition, 2013, 41(4): 844-857. PMID:23382457. PMCID:PMC3608454.

2012

Lu H, Cui JY, Gunewardena S, Yoo B, Zhong XB, and Klaassen CD. Hepatic ontogeny and tissue distribution of mRNAs of epigenetic modifiers in mice using RNA-Sequencing. Epigenetics, 2012, 7(8):1-16. PMID:22772165. PMCID:PMC3427287.

Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, and Li L. Non-canonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell, 2012, 150(2): 351-365. PMID:22817897. PMCID:PMC4492542.

Cui JY, Gunewardena SS, Yoo B, Liu J, Renaud HJ, Lu H, Zhong XB, and Klaassen CD. RNA-Seq reveals different mRNA abundance of transporters and their alternative transcript isoforms during liver development. Toxicological Sciences, 2012, 127(2):592-608. PMID:22454430. PMCID:PMC3355312.

Peng L, Yoo B, Gunewardena SS, Lu H, Klaassen CD, and Zhong XB. RNA-Seq reveals dynamic changes of mRNA abundance of cytochrome P450s and their alternative transcripts during liver development. Drug Metabolism and Disposition, 2012, 40(6):1198-1209. PMID:22434873. PMCID:PMC3362789.

Wang Y, Kang G, Liu J, Zhao M, Wu J, Zhang X, Li Y, Zhong XB, Yang Y, and Peng S. Novel potassium N-[(2S, 3R, 4R, 5R)-2,3,4,5,6-pentahydroxylhex-1-yl]-L-amino acid dichloroplatinates (II) with high anti-tumor activity and low side reaction. Metallomics, 2012, 4(5):441-447. PMID:22488043.

Cui JY, Aleksunes LM, Tanaka Y, Fu ZD, Guo Y, Guo GL, Lu H, Zhong XB, and Klaassen CD. Bile acids via FXR initiate the expression of major transporters involved in the enterohepatic circulation of bile acids in newborn mice. American Journal of Physiology: Gastrointestinal and Liver Physiology, 2012, 302(9):G979-G996. PMID:22268101. PMCID:PMC3362079.

Li Y and Zhong XB. Epigenetic regulation of developmental expression of Cyp2d genes in mouse liver. Acta Pharmaceutica Sinica B. 2012, 2(2):144-156.

Li D, Gaedigk R, Hart SN, Leeder JS, and Zhong XB. The role of CYP3A4 mRNA transcript with shortened 3’-UTR in hepatocyte differentiation, liver development, and response to drug induction. Molecular Pharmacology, 2012, 81(1): 86-96. PMID:21998292. PMCID:PMC3250109.

Li H, Wolfe A, Septer S, Edwards G, Zhong XB, Abdulkarim AB, Ranganathan S, and Apte U. Deregulation of hippo kinase signaling in human hepatic malignancies. Liver International, 2012, 32(1):38-47. PMID:22098159. PMCID:PMC4175712.

Before 2012

Rodova M, Lu Q, Li Y, Woodbury B, Crist J, Gardner B, Yost J, Zhong XB, Anderson HC, and Wang J. Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone modifications. Journal of Bone and Mineral Research, 2011, 26(8):1974-1986. PMID:21452283. PMCID:PMC3353550. PDF.

Wang L, Li F, Lu J, Li G, Li D, Zhong XB, Guo GL, and Ma X. The Chinese herbal medicine sophora flavescens activates pregnane X receptor. Drug Metabolism and Disposition, 2010, 38(12):2226-2231. PMID:20736322. PMCID:PMC2993459. PDF.

Li GD, Thomas AM, Hart SN, Zhong XB, Wu D, and Guo GL. Novel insight of transcriptional activation of SHP by FXR: chromatin looping of promoter and downstream FXR response elements in Nr0b2 gene. Molecular Endocrinology, 2010, 24(7):1404-1412. PMID:20444884. PMCID:PMC2903909. PDF.

Hart SN, Li Y, Nakamoto K, Subileau E, Steen D, and Zhong XB. A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues. Drug Metabolism and Disposition, 2010, 38(6):988-994. PMID: 20228232, PMCID:PMC2879958. PDF.

Thomas AM, Hart SN, Kong B, Fang J, Zhong XB, and Guo GL. Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology, 2010, 51(4):1410-1419. PMID:20091679. PMCID:PMC4855519. PDF.

Li Y, Buckley D, Wang S, Klaassen CD, and Zhong XB. Genetic polymorphisms in the TATA box and upstream phenobarbital responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver. Drug Metabolism and Disposition, 2009, 37(9):1978-1986. PMID:19541828, PMCID:PMC2729330. PDF.

Sim SC, Miller WL, Zhong XB, Arlt W, Ogata T, Ding XX, Wolf R, Pandey AV, Henderson C, Porter T, Masters BS, Daly AK, Nebert, DW, and Ingelman-Sundberg M. Nomenclature for cytochrome P450 oxidoreductase alleles. Pharmacogenetics and Genomics, 2009, 19(7):565-566. PMID:19535965, PMCID:PMC2753199. PDF.

Cui JY, Leager RL, Zhong XB, and Klaassen CD. Ontogenic expression of hepatic Ahr mRNA is associated with histone H3K4 dimethylation during mouse liver development. Toxicology Letters, 2009, 189(3):184-190. PMID:19481593, PMCID:PMC2762423. PDF.

Li Y, Cui Y, Hart SN, Klaassen CD, and Zhong XB. Dynamic histone methylation is associated with ontogenic expression of Cyp3a genes during mouse liver maturation. Molecular Pharmacology, 2009, 75(5):1171-1179. PMID:19188337, PMCID:PMC2672803. PDF.

Hart SN, Cui Y, Klaassen CD, and Zhong XB. Three patterns of cytochrome P450 gene expression during liver maturation in mice. Drug Metabolism and Disposition, 2009, 37(1):116-121. PMID:18845660. PMCID:PMC2683655. PDF.

Hart SN and Zhong XB. P450 oxidoreductase: genetic polymorphisms and implications to drug metabolism and toxicity. Expert Opinion on Drug Metabolism and Toxicology, 2008, 4(4):439-452. Review. PMID:18433346. PDF.

Hart SN, Wang S, Nakamoto K, Wesselman C, Li Y, and Zhong XB. Genetic polymorphisms in cytochrome P450 oxidoreductase influence microsomal P450-catelyzed drug metabolism. Pharmacogenetics and Genomics, 2008, 18(1):11-24. PMID:18216718. PDF.

Hart SN, Li Y, Nakamoto K, Wesselman C, and Zhong XB. Novel SNPs in cytochrome P450 oxidoreductase. Drug Metabolism and Pharmacokinetics, 2007, 22(4):322-326. PMID:17827787. PDF.

Nakamoto K, Kidd JR, Jenison RD, Klaassen CD, Wan YJ, Kidd KK, and Zhong XB. Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips. Pharmacogenetics and Genomics, 2007, 17(2):103-114. PMID:17301690. PDF.

Nakamoto K, Wang S, Jenison RD, Guo GL, Klaassen CD, Wan YJ, and Zhong XB. Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene. BMC Genetics, 2006; 7:29-37. PMID:16709249. PMCID:PMC1488870. PDF.

Bai SL, Zhong XB, Ma LG, Zheng WJ, Fan LM, Wei N, and Deng XW. A simple and reliable assay for detecting specific nucleotide sequence variations in plants using optical thin-film biosensor chips. The Plant Journal, 2007; 49:354-366. PMID:17156412. PDF.

Zhong XB, Leng L, Beitin A, Chen R, McDonald C, Hsiao B, Jenison RD, Kang I, Park SH, Lee A, Gregersen P, Thuma P, Bray-Ward P, Ward DC, and Bucala R. Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies. Nucleic Acids Research. 2005; 33(13):e121. PMID:16077028. PMCID:PMC1182331. PDF

Zhong XB, Reynolds R, Kidd JR, Kidd KK, Jenison R, Marlar RA, and Ward DC. Single-nucleotide polymorphism genotyping on optical thin-film biosensor chips. Proceedings of the National Academy of Sciences USA, 2003; 100(20):11559-11564. PMID:12975525. PMCID:PMC208797. PDF.

Zhong, XB, Lizardi PM, Huang XH, Bray-Ward PL, and Ward DC. Visualization of oligonucleotide probes and point mutations in interphase nuclei and DNA fibers using rolling circle DNA amplification. Proceedings of the National Academy of Sciences USA, 2001; 98(7):3940-3945. PMID:11274414. PMCID:PMC31158. PDF.

Grichtchenko II, Choi IY, Zhong XB, Bray-Ward P, Russell JM, and Boron WF. Cloning, characterization, and chromosomal mapping of a human electroneutral Na+-driven Cl-NCO3 exchanger. Journal of Biological Chemistry, 2001, 276 (11):8358-8363. PMID:11133997. PDF.

De Jong JH, Zhong XB, Fransz PF, Wennekes-van Eden J, Jacobsen E, and Zabel P. High resolution FISH reveals the molecular and chromosomal organization of repetitive sequences of individual tomato chromosomes. Chromosome Today, 2000; 13:267-275. PDF.

Zhong XB, Bodeau J, Fransz PF, Williamson VM, van Kammen A, de Jong JH, and Zabel P. FISH to meiotic pachytene chromosomes of tomato locates the root-knot nematode resistance gene Mi-1 and the acid phosphatase gene Aps-1 near the junction of euchromatin and pericentromeric heterochromatin of chromosome arms 6S and 6L, respectively. Theoretical & Applied Genetics, 1998; 98:365-370. PDF.

Zhong XB, Fransz PF, Wennekes J, van Kammen A, de Jong JH, and Zabel P. Fluorescence in situ hybridization to pachytene chromosomes and extended DNA fibres in plants. Acta Genetica Sinica, 1998; 25(2):142-149.

Zhong XB, Fransz PF, Wennekes-van Eden J, Ramanna MS, van Kammen A, Zabel P, and de Jong JH. FISH studies reveal the molecular and chromosomal organisation of individual telomere domains in tomato. Plant Journal, 1998; 13(4):507-517. PMID:9680996. PDF.

Zhong XB, Fransz PF, de Jong JH, and Zabel P. High resolution physical mapping by fluorescence in situ hybridisation. Hereditas, 1997; 19(3): 44-48.

Zhong XB, Fransz PF, Wennekes-van Eden J, Zabel P, van Kammen A, and de Jong JH. High resolution mapping by fluorescence in situ hybridisation to pachytene chromosomes and extended DNA fibres. Plant Molecular Biology Reporter, 1996; 14:232-242. PDF.

Zhong XB, de Jong JH, and Zabel P. Preparation of tomato meiotic pachytene and mitotic metaphase chromosomes suitable for fluorescence in situ hybridisation (FISH). Chromosome Research, 1996; 4(1):24-28. PMID:8653264. PDF.