Stephanie C. Piekos

Ph.D. Student (2013-2018)

Current position: Senior Scientist at Boehringer Ingelheim

Education

2009-2013
BSc. in Molecular & Cell Biology
University of Connecticut
2013-2018
Ph.D. in Pharmacology
University of Connecticut

 

Professional Experience

2016
A Summer Internship at Boehringer Ingelheim
2018-
Senior Scientist at Boehringer Ingelheim

 

Professional Societies

2014-
Member, American Society for Pharmacology and Experimental Therapeutics (ASPET)

 

Honors and Awards

04/2016
A Graduate Student Travel Award ($1,000) from ASPET at the Experimental Biology 2016 Meeting in San Diego, CA
04/2017
A Graduate Student Travel Award ($1,000) from ASPET at the Experimental Biology 2017 Meeting in Chicago, IL
04/2017
The Philip Rosenberg & Steven D. Cohen Graduate Fellowship ($2,000) in the area of Pharmacology and Toxicology
08/2017-05/2018
An AFPE Pre-Doctoral Fellowship in Pharmaceutical Sciences ($10,000) from the American Foundation for Pharmaceutical Education

 

Poster Presentations

04/2016
Experimental Biology Meeting, San Diego, CA
Piekos SC, Peng L, and Zhong XB. The temporal expression and regulation of an imprinted gene network during postnatal liver development in mice
04/2016
Experimental Biology Meeting, San Diego, CA
Tien YC, Pope C, Piekos SC, and Zhong XB. 2016. Neonatal phenobarbital exposure results in decreased proton pump inhibition by omeprazole in adult mouse stomach
04/2017
Experimental Biology Meeting, Chicago, IL
Piekos SC, Chen L, and Zhong XB. Influence on drug efficacy in adult life by drug treatment at neonatal ages
09/2017
21st North American ISSX Meeting, Providence, Rhode Island
Piekos SC, Chen L, Ma X, Wang P, and Zhong XB. Short- and long-term effects on cytochrome P450 expression and induction following phenytoin exposure at the neonatal age
09/2017
21st North American ISSX Meeting, Providence, Rhode Island
Chen L, Bao Y, Piekos SC, and Zhong XB. The role of hepatocyte nuclear factor 1 alpha (HNF1a) and long non-coding RNA HNF1a antisense 1 (HNF1a-AS1) in the regulation of cytochrome P450s and nuclear receptors in liver cells
02/2018
Keystone Symposium Noncoding RNAs: Form, Function, Physiology, Keystone, CO
Bao Y, Chen L, Piekos SC, and Zhong XB. The role of long non-coding RNAs HNF1a-AS1 and HNF4a-AS1 in the regulation of drug metabolizing cytochrome P450 enzymes and nuclear receptors in liver cells
04/2018
Experimental Biology Meeting, San Diego, CA
Chen L, Bao Y, Piekos SC, and Zhong XB. A transcriptional regulatory network containing nuclear receptors and long non-coding RNAs controls basal and induced expression of cytochrome P450s in liver cells
04/2018
Experimental Biology Meeting, San Diego, CA
Shi J, Piekos SC, Chen L, Jing X, Zhong XB, and Zhu HJ. Short- and long-term effects of phenytoin exposure on the liver proteome of neonatal and adult mice using SWATH-MS technology

 

Oral Presentations

02/2016
Pharmaceutical Science Research Symposium, Storrs, CT
“Variations in drug metabolism and personalized medicine”

 

Ph.D. Thesis Dissertation
Consequences of antiepileptic drug exposure during postnatal liver development on cytochrome P450 expression and metabolism. Doctoral Dissertations, 2018.

 

Publications

Peng L, Paulson A, Li H, Piekos SC, He X, Li L, and Zhong XB. Developmental programming of long non-coding RNAs during postnatal liver maturation in mice. PLoS ONE, 2014, 9(12):e114917. PMID:25503252. PMCID:PMC4263710. DOI: 10.1371/journal.pone.0114917.

Peng L, Piekos SC, Guo GL, and Zhong XB. Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver. Acta Pharmaceutica Sinica B. 2016, 6(5):453-459. PMID:27709014. PMCID:PMC5045554. DOI: 10.1016/j.apsb.2016.07.015.

Tien YC, Piekos SC, Pope C, and Zhong XB. Phenobarbital treatment at a neonatal age results in decreased efficacy of omeprazole in adult mice. Drug Metabolism and Disposition, 2017, 45(3):330-335. PMID:28062542. PMCID:PMC5325062. DOI: 10.1124/dmd.116.073601.

Piekos SC, Pope C, Ferrara A, and Zhong XB. Impact of drug treatment at neonatal ages on variability of drug metabolism and drug-drug interactions in adult life. Current Pharmacology Reports, 2017, 3(1):1-9. PMID:28344923. PMCID:PMC5362116. DOI: 10.1007/s40495-016-0078-6.

Piekos SC and Zhong XB. Supplement on Editors’ Picks of Drug Metabolism and Disposition, 43:1938-1945. World Biomedical Frontiers, Editors’ Picks, 2017 Mar 12.

Peng L, Piekos SC, Guo GL, and Zhong XB. Role of farnesoid X receptor in the determination of liver transcriptome during postnatal maturation in mice. Nuclear Receptor Research, 2017, 4:101308. PMID: 29795774. PMCID: PMC5962295. DOI: 10.11131/2017/101308.

Pope C, Piekos SC, Chen L, Mishra S, and Zhong XB. The role of H19, a long non-coding RNA, in mouse liver postnatal maturation. PLoS ONE, 2017, 12(11):e0187557. PMID: 29099871. PMCID: PMC5669494. DOI: 10.1371/journal.pone.0187557

Chen L, Bao Y, Piekos SC, Zhu K, Zhang L, and Zhong XB. A transcriptional regulatory network containing nuclear receptors and lncRNAs controls basal and drug-induced expression of cytochrome P450s in HepaRG cells . Molecular Pharmacology, 2018, 94(1):749-759. PMID: 29691280. PMCID: PMC5988030. DOI: 10.1124/mol.118.112235.

Piekos SC, Chen L, Wang P, Shi J, Yaqoob S, Zhu HJ, Ma X, and Zhong XB. Consequences of phenytoin exposure on hepatic cytochrome P450 expression during postnatal liver maturation in mice. Drug Metabolism and Disposition, 2018, 46(8):1241-1250. PMID: 29884652. PMCID: PMC6053591 DOI: 10.1124/dmd.118.080861.

Hoang TH, Zhao Y, Lam Y, Piekos S, Han YC, Reilly C, Joshi P, Hong SH, Sung CO, Giardina C, Shin DG. BioTarget: A Computational Framework Identifying Cancer Type Specific Transcriptional Targets of Immune Response Pathways. Sci Rep, 2019, 9(1):9029. PMID: 31227749 PMCID: PMC6588588 DOI: 10.1038/s41598-019-45304-x.

Zhao Y, Piekos S, Hoang TH, Shin DG. A framework using topological pathways for deeper analysis of transcriptome data. BMC Genomics. 2020, 21(Suppl 1):834. PMID: 32138666. PMCID: PMC7057456. DOI: 10.1186/s12864-019-6155-6.

 

Ph.D. Thesis

Piekos SC. Consequences of antiepileptic drug exposure during postnatal liver development on cytochrome P450 expression and metabolism. Doctoral Dissertations, 2018, 1850. https://opencommons.uconn.edu/dissertations/1850.

 

Contact Information
Emailstephanie.piekos@uconn.edu
Mailing AddressBoehringer Ingelheim, 900 Ridgebury Road, Ridgefield, CT 06877